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Article

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Aarup Annemarie, Pedersen Tanja X, Junker Nanna, Christoffersen Christina, Bartels Emil D, Madsen Marie, Nielsen Carsten H, Nielsen Lars B

Abstract excerpt

OBJECTIVE: Atherosclerotic lesions contain hypoxic areas, but the pathophysiological importance of hypoxia is unknown. Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor in cellular responses to hypoxia. We investigated the hypothesis that HIF-1α has effects on macrophage biology that promotes atherogenesis in mice. APPROACH AND RESULTS: Studies with molecular probes, immunostaining, and laser...

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Source

Identifiers

PMID: 27444197
DOI: 10.1161/ATVBAHA.116.307830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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