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Article

Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling.

Cardiovascular research - 1 Sept 2013

Nakayama Taisuke, Kurobe Hirotsugu, Sugasawa Noriko, Kinoshita Hajime, Higashida Mayuko, Matsuoka Yuki, Yoshida Yasushi, Hirata Yoichiro, Sakata Mie, Maxfield Mark W, Shimabukuro Michio, Takahama Yousuke, Sata Masataka, Tamaki Toshiaki, Kitagawa Tetsuya, Tomita Shuhei

Abstract excerpt

AIMS: Excessive vascular remodelling leads to progression of a wide range of vasculopathies, and the immune response to intimal injuries is crucial in this process. This vascular remodelling occurs in the hypoxic microenvironment and is closely related to the immune system. Macrophages play a key role in immunological-cell-mediated arterial remodelling. In this study, we clarified the role of macrophage-derived...

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PMID: 23752975
DOI: 10.1093/cvr/cvt146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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