Article
AMP-Activated Protein Kinase α1 in Macrophages Promotes Collateral Remodeling and Arteriogenesis in Mice In Vivo.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Zhu Huaiping, Zhang Miao, Liu Zhaoyu, Xing Junjie, Moriasi Cate, Dai Xiaoyan, Zou Ming-Hui
Abstract excerpt
OBJECTIVE: AMP-activated protein kinase (AMPK), an energy and redox sensor, is activated in response to various cellular stresses, including hypoxia, nutrient deprivation, oxidative stress, and fluid shear stress at the site of vessel blockade. The activation of AMPK is involved in angiogenesis. However, it is unknown whether AMPK can influence arteriogenesis. Here, we demonstrate the contribution of macrophage...
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