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Article

Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish.

Nature communications - 19 May 2017

Gerri Claudia, Marín-Juez Rubén, Marass Michele, Marks Alora, Maischein Hans-Martin, Stainier Didier Y R

Abstract excerpt

Macrophages are known to interact with endothelial cells during developmental and pathological angiogenesis but the molecular mechanisms modulating these interactions remain unclear. Here, we show a role for the Hif-1α transcription factor in this cellular communication. We generated hif-1aa;hif-1ab double mutants in zebrafish, hereafter referred to as hif-1α mutants, and find that they exhibit impaired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28524872
DOI: 10.1038/ncomms15492
PMCID: PMC5493593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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