Article
Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Zhu Lin, Giunzioni Ilaria, Tavori Hagai, Covarrubias Roman, Ding Lei, Zhang Youmin, Ormseth Michelle, Major Amy S, Stafford John M, Linton MacRae F, Fazio Sergio
Abstract excerpt
OBJECTIVE: Antiatherosclerotic effects of tumor necrosis factor-α (TNF-α) blockade in patients with systemic inflammatory states are not conclusively demonstrated, which suggests that effects depend on the cause of inflammation. Macrophage LRP1 (low-density lipoprotein receptor-related protein 1) and apoE contribute to inflammation through different pathways. We studied the antiatherosclerosis effects of TNF-α...
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