Article
Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E-Deficient Mice.
Circulation - 7 Jun 2016
Higashi Yusuke, Sukhanov Sergiy, Shai Shaw-Yung, Danchuk Svitlana, Tang Richard, Snarski Patricia, Li Zhaohui, Lobelle-Rich Patricia, Wang Meifang, Wang Derek, Yu Hong, Korthuis Ronald, Delafontaine Patrice
Abstract excerpt
BACKGROUND: We have previously shown that systemic infusion of insulin-like growth factor-1 (IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic burden in apolipoprotein E (Apoe)-deficient mice. Monocytes/macrophages express high levels of IGF-1 receptor (IGF1R) and play a pivotal role in atherogenesis, but the potential effects of IGF-1 on their function are unknown. METHODS AND...
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