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Article

Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase.

Cardiovascular research - 23 Apr 2021

Seneviratne Anusha, Cave Luke, Hyde Gareth, Moestrup Soren Kragh, Carling David, Mason Justin C, Haskard Dorian O, Boyle Joseph James

Abstract excerpt

AIMS: Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque haemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and activating transcription factor 1 (ATF1). The antidiabetic drug metformin may also activate AMPK-dependent signalling. Hypothesis: Metformin systematically induces atheroprotective genes in macrophages via AMPK and...

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Identifiers

PMID: 32667970
DOI: 10.1093/cvr/cvaa171
PMCID: PMC8064441

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