Article
Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down.
Journal of the American Heart Association - 20 Aug 2013
Ma Hongling, Zhong Wenbin, Jiang Yingliang, Fontaine Coralie, Li Shiqian, Fu Jiangnan, Olkkonen Vesa M, Staels Bart, Yan Daoguang
Abstract excerpt
BACKGROUND: Nuclear receptor Rev-erbα plays important roles in circadian clock timing, lipid metabolism, adipogenesis, and vascular inflammation. However, the role of Rev-erbα in atherosclerotic lesion development has not been assessed in vivo. METHODS AND RESULTS: The nuclear receptor Rev-erbα was knocked down in mouse haematopoietic cells by means of shRNA-lentiviral transduction, followed by bone marrow...
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