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Article

Myeloid Drp1 Deficiency Limits Revascularization in Ischemic Muscles via Inflammatory Macrophage Polarization and Metabolic Reprograming

2023-11-06

Abstract excerpt

<h4>ABSTRACT</h4> In the preclinical model of peripheral arterial disease (PAD), M2-like anti-inflammatory macrophage polarization and angiogenesis are required for revascularization. The regulation of cell metabolism and inflammation in macrophages is tightly linked to mitochondrial dynamics. Drp1, a mitochondrial fission protein, has shown context-dependent macrophage phenotypes with both pro- and anti-inflamma...

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Literature Corpus work
dcb39229-356f-587b-b22a-b4e80cda1967
DOI
10.1101/2023.11.04.565656
Open publication

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