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Article

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2015

Chaudhari Sweena M, Sluimer Judith C, Koch Miriam, Theelen Thomas L, Manthey Helga D, Busch Martin, Caballero-Franco Celia, Vogel Frederick, Cochain Clément, Pelisek Jaroslav, Daemen Mat J, Lutz Manfred B, Görlach Agnes, Kissler Stephan, Hermanns Heike M, Zernecke Alma

Abstract excerpt

OBJECTIVE: Although immune responses drive the pathogenesis of atherosclerosis, mechanisms that control antigen-presenting cell (APC)-mediated immune activation in atherosclerosis remain elusive. We here investigated the function of hypoxia-inducible factor (HIF)-1α in APCs in atherosclerosis. APPROACH AND RESULTS: We found upregulated HIF1α expression in CD11c(+) APCs within atherosclerotic plaques of...

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Source

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Identifiers

PMID: 26404487
DOI: 10.1161/ATVBAHA.115.306171
PMCID: PMC4618712

Genes

STAT3
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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