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Article

The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer.

Cold Spring Harbor perspectives in medicine - 1 Aug 2016

Hodges Courtney, Kirkland Jacob G, Crabtree Gerald R

Abstract excerpt

During the last decade, a host of epigenetic mechanisms were found to contribute to cancer and other human diseases. Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated complexes in cancer. Recurrent mutations arise in genes...

Topics

Animals
Chromatin
Chromosomal Proteins, Non-Histone
DNA Repair
DNA-Binding Proteins
Drosophila melanogaster
Epigenomics
Gene Expression Regulation
Humans
Mutation
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Saccharomyces cerevisiae

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27413115
DOI: 10.1101/cshperspect.a026930
PMCID: PMC4968166

Genes

ARID2
PBRM1
SMARCA4
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27413115-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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