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Article

The BAF complex in development and disease

21 Mar 2019

Abstract excerpt

The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF complex evolved an immense complexity with a high number of subunits encoded by gene families. In this way, tissue-specific BAF function and regulation of development begin with the combinatorial assembly...

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PMID: 30898143
DOI: 10.1186/s13072-019-0264-y

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