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Article

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Nature genetics - 1 Jun 2013

Kadoch Cigall, Hargreaves Diana C, Hodges Courtney, Elias Laura, Ho Lena, Ranish Jeff, Crabtree Gerald R

Abstract excerpt

Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignancies. To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18....

Topics

Animals
Cells, Cultured
Chromosomal Proteins, Non-Histone
Gene Frequency
Genes, Tumor Suppressor
Humans
Mice
Mutation
Neoplasms
Oncogenes
Protein Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteomics

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23644491
DOI: 10.1038/ng.2628
PMCID: PMC3667980

Genes

BRD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23644491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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