Article

ARID1A regulates histone octamer transfer activity of human canonical BAF complex

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutations that impact subunits of mammalian SWI/SNF (mSWI/SNF or BAF) chromatin remodeling complexes are found in over 20% of human cancers. Among these subunits, ARID1A is the most frequently mutated gene, occurring in over 8% of various cancers. The majority of ARID1A mutations are frameshift or nonsense mutations, causing loss of function. Previous studies have suggested that ARID1A may facil...

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Literature Corpus work: ff8754c5-d94c-5180-b605-0900c32b1630
DOI: 10.1101/2025.05.21.655315

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