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Article

Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.

Scientific reports - 11 Jul 2016

Umemura Takeji, Joshita Satoru, Yamazaki Tomoo, Komatsu Michiharu, Katsuyama Yoshihiko, Yoshizawa Kaname, Tanaka Eiji, Ota Masao

Abstract excerpt

Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are liver-specific autoimmune conditions that are characterized by chronic hepatic damage and often lead to cirrhosis and hepatic failure. Specifically, the protein tyrosine phosphatase N22 (PTPN22) gene encodes the lymphoid protein tyrosine phosphatase, which acts as a negative regulator of T-cell receptor signaling. A missense single nucleotide...

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Source

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Identifiers

PMID: 27406031
DOI: 10.1038/srep29770
PMCID: PMC4942688

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.PMID 27406031Read ↗

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