PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.

Abstract excerpt

OBJECTIVES: The present study aimed to detect a possible association between PTPN22 gene polymorphisms and rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Chinese Han population. METHODS: 7 PTPN22 SNPs were genotyped in 358 patients with RA and 713 patients with SLE, as well as 564 RA controls and 672 SLE controls by Restriction Fragment Length Polymorphism (RFLP). Association analyses were...

Topics

• Adolescent
• Adult
• Antibodies, Antinuclear
• Arthritis, Rheumatoid
• Case-Control Studies
• China
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease