Article
A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis.
Hepatology (Baltimore, Md.) - 1 Oct 2024
Hitomi Yuki, Ueno Kazuko, Aiba Yoshihiro, Nishida Nao, Kono Michihiro, Sugihara Mitsuki, Kawai Yosuke, Kawashima Minae, Khor Seik-Soon, Sugi Kazuhiro, Kouno Hirotaka, Kohno Hiroshi, Naganuma Atsushi, Iwamoto Satoru, Katsushima Shinji, Furuta Kiyoshi, Nikami Toshiki, Mannami Tomohiko, Yamashita Tsutomu, Ario Keisuke, Komatsu Tatsuji, Makita Fujio, Shimada Masaaki, Hirashima Noboru, Yokohama Shiro, Nishimura Hideo, Sugimoto Rie, Komura Takuya, Ota Hajime, Kojima Motoyuki, Nakamuta Makoto, Fujimori Naoyuki, Yoshizawa Kaname, Mano Yutaka, Takahashi Hironao, Hirooka Kana, Tsuruta Satoru, Sato Takeaki, Yamasaki Kazumi, Kugiyama Yuki, Motoyoshi Yasuhide, Suehiro Tomoyuki, Saeki Akira, Matsumoto Kosuke, Nagaoka Shinya, Abiru Seigo, Yatsuhashi Hiroshi, Ito Masahiro, Kawata Kazuhito, Takaki Akinobu, Arai Kuniaki, Arinaga-Hino Teruko, Abe Masanori, Harada Masaru, Taniai Makiko, Zeniya Mikio, Ohira Hiromasa, Shimoda Shinji, Komori Atsumasa, Tanaka Atsushi, Ishigaki Kazuyoshi, Nagasaki Masao, Tokunaga Katsushi, Nakamura Minoru
Abstract excerpt
BACKGROUND AND AIMS: Previous genome-wide association studies (GWAS) have indicated the involvement of shared (population-nonspecific) and nonshared (population-specific) susceptibility genes in the pathogenesis of primary biliary cholangitis (PBC) among European and East-Asian populations. Although a meta-analysis of these distinct populations has recently identified more than 20 novel PBC susceptibility loci,...
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