Article
Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2011
Bu De-xiu, Tarrio Margarite, Maganto-Garcia Elena, Stavrakis George, Tajima Goro, Lederer James, Jarolim Petr, Freeman Gordon J, Sharpe Arlene H, Lichtman Andrew H
Abstract excerpt
OBJECTIVE: Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals on interaction with its 2 ligands, PD-L1 and PD-L2. We studied the contribution of the PD-1 pathway to regulation of T cells that promote atherosclerotic lesion formation and inflammation. METHODS AND RESULTS: We show that compared with Ldlr-/- control mice, Pd1-/-Ldlr-/- mice developed larger lesions with...
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