Article

Pro-atherogenic diet accelerates tumor growth in mice through IL-1β and myeloid cell-derived VEGF-A

2020-10-20

Abstract excerpt

<title>Abstract</title> <p><bold>Aims:</bold> Myeloid inflammatory cells are recruited to the tumor microenvironment and subsequently educated <italic>in situ</italic> to acquire a pro-invasive, pro-angiogenic and immunosuppressive phenotype. Components of the metabolic syndrome are known to aggravate tumorigenesis in part through myeloid cell activation. We hypothesized that consumption of a high fat/high choles...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7c258f6-0f64-5930-b1ab-303ba67a6923
DOI: 10.21203/rs.3.rs-86825/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pro-atherogenic diet accelerates tumor growth in mice through IL-1β and myeloid cell-derived VEGF-ADOI 10.21203/rs.3.rs-86825/v1Read

Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cellsSemantic proximity Read

PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in ObesitySemantic proximity Read

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppressionSemantic proximity Read

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer ProgressionSemantic proximity Read

Functional crosstalk between T cells and monocytes in cancer and atherosclerosisSemantic proximity Read

Atherosclerosis and Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside—Part 1Semantic proximity Read

Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression.Semantic proximity Read

Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironmentSemantic proximity Read

The Journey to Clonal Hematopoiesis and Applications Incardiovascular Disease and CancerSemantic proximity Read

Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters.Semantic proximity Read

Glycolytic reprogramming fuels myeloid cell-driven hypercoagulabilitySemantic proximity Read

miR487a-3p and miR6855-3p Facilitate Macrophage Pro-inflammatory Polarization and Lipid Accumulation in AtherosclerosisSemantic proximity Read