Article
Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.
The Journal of clinical investigation - 1 Oct 2007
Gotsman Israel, Grabie Nir, Dacosta Rosa, Sukhova Galina, Sharpe Arlene, Lichtman Andrew H
Abstract excerpt
T lymphocyte responses promote proatherogenic inflammatory events, which are influenced by costimulatory molecules of the B7 family. Effects of negative regulatory members of the B7 family on atherosclerosis have not been described. Programmed death-ligand 1 (PD-L1) and PD-L2 are B7 family members expressed on several cell types, which inhibit T cell activation via binding to programmed death-1 (PD-1) on T cells....
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