Article
Anti-tumor necrosis factor-α therapy increases plaque burden in a mouse model of experimental atherosclerosis.
Atherosclerosis - 1 Oct 2018
Oberoi Raghav, Vlacil Ann-Kathrin, Schuett Jutta, Schösser Florian, Schuett Harald, Tietge Uwe J F, Schieffer Bernhard, Grote Karsten
Abstract excerpt
BACKGROUND AND AIMS: Atherosclerosis is critically fueled by vascular inflammation through oxidized lipids and inflammatory cytokines such as tumor necrosis factor (TNF)-α. Genetic disruption of Tnf-α reduces atherosclerosis in experimental mouse models. However, less is known about the therapeutic potential of Tnf-α blockage by pharmacological inhibitors such as monoclonal antibodies, which are already approved...
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