Article

Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis

2023-06-04

Abstract excerpt

<h4>Background</h4> The interleukin-1 (IL-1) family and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome contribute to atherogenesis but the underlying mechanism are incompletely understood. Unlike IL-1β, IL-1α is not dependent on the NLRP3 inflammasome to exert its pro-inflammatory effects. Here, a non-genetic model was applied to characterize the role of IL-1α, IL-1β and NLRP3 for the pathogenesis...

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Literature Corpus work: 6e161d3e-f368-58b8-b544-2ce164acca88
DOI: 10.1101/2023.05.31.543077

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