Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis.

Cardiovascular diabetology - 6 Nov 2017

Bruen Robyn, Curley Sean, Kajani Sarina, Crean Daniel, O'Reilly Marcella E, Lucitt Margaret B, Godson Catherine G, McGillicuddy Fiona C, Belton Orina

Abstract excerpt

BACKGROUND: Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages. We hypothesized that liraglutide could limit atherosclerosis progression in vivo via modulation of the inflammatory response. METHODS: Human THP-1 macrophages and bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Hypoglycemic Agents

Share to Leukocytes, Mononuclear

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 29110715
DOI: 10.1186/s12933-017-0626-3
PMCID: PMC5674826

Genes

CCR7
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis.PMID 29110715Read ↗

LRG1 promotes atherosclerosis by activating macrophagesSemantic proximity Read ↗

Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E-Deficient Mice.Semantic proximity Read ↗

Understanding the role of alternative macrophage phenotypes in human atherosclerosis.Semantic proximity Read ↗

The Role of Macrophages in Atherosclerosis: Pathophysiologic Mechanisms and Treatment Considerations.Semantic proximity Read ↗

Macrophage Plasticity and Atherosclerosis TherapySemantic proximity Read ↗

Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases.Semantic proximity Read ↗

M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human AtherosclerosisSemantic proximity Read ↗

Macrophages and T cells in atherosclerosis: a translational perspectiveSemantic proximity Read ↗

Functional diversity of macrophages in vascular biology and disease.Semantic proximity Read ↗

Macrophage Phenotypes and Their Modulation in AtherosclerosisSemantic proximity Read ↗

Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.Semantic proximity Read ↗

Deciphering Macrophage Phenotypes upon Lipid Uptake and AtherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.