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Article

Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.

Circulation - 29 Jun 2004

Pan Jie-Hong, Sukhova Galina K, Yang Jing-Tian, Wang Bing, Xie Tao, Fu Huanxiang, Zhang Yaou, Satoskar Abhay R, David John R, Metz Christine N, Bucala Richard, Fang Kenneth, Simon Daniel I, Chapman Harold A, Libby Peter, Shi Guo-Ping

Abstract excerpt

BACKGROUND: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine expressed widely by vascular cells. However, scant in vivo evidence supports direct participation of MIF in atherogenesis. Therefore, we investigated whether deficiency of MIF modulates atherosclerotic lesion formation and composition in low-density lipoprotein receptor-deficient (LDLr-/-) mice. METHODS AND RESULTS:...

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Source

Identifiers

PMID: 15197138
DOI: 10.1161/01.CIR.0000134704.84454.D2

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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