Article
Ontogeny of SERT Expression and Antidepressant-like Response to Escitalopram in Wild-Type and SERT Mutant Mice.
The Journal of pharmacology and experimental therapeutics - 1 Aug 2016
Mitchell Nathan C, Gould Georgianna G, Koek Wouter, Daws Lynette C
Abstract excerpt
Depression is a disabling affective disorder for which the majority of patients are not effectively treated. This problem is exacerbated in children and adolescents for whom only two antidepressants are approved, both of which are selective serotonin reuptake inhibitor (SSRIs). Unfortunately SSRIs are often less effective in juveniles than in adults; however, the mechanism(s) underlying age-dependent responses to...
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