Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.

ACS chemical neuroscience - 15 Oct 2014

Angoa-Pérez Mariana, Kane Michael J, Briggs Denise I, Herrera-Mundo Nieves, Sykes Catherine E, Francescutti Dina M, Kuhn Donald M

Abstract excerpt

Reductions in function within the serotonin (5HT) neuronal system have long been proposed as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the most common treatment for depression, and their therapeutic effect is generally attributed to their ability to increase the synaptic levels of 5HT. Tryptophan hydroxylase 2 (TPH2) is the initial and rate-limiting enzyme in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Sucrose
Share to Quinine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin

Share to Stress, Psychological

Share to Synaptosomes

Share to Taste Perception

Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 25089765
DOI: 10.1021/cn500096g
PMCID: PMC4777283

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.PMID 25089765Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.Semantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter.Semantic proximity Read ↗

Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.Semantic proximity Read ↗

Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin.Semantic proximity Read ↗

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.Semantic proximity Read ↗

TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin systemSemantic proximity Read ↗

Tryptophan hydroxylase-2 controls brain serotonin synthesis.Semantic proximity Read ↗

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.