Article
The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice.
Brain research - 25 Aug 2009
Joeyen-Waldorf Jennifer, Edgar Nicole, Sibille Etienne
Abstract excerpt
Mood disorders are influenced by genetic make-up and differentially affect men and women. The s/l promoter polymorphism in the serotonin transporter (SERT) gene moderates both trait emotion and the vulnerability to develop depressive states in humans. Similarly, male mice lacking SERT (Knockout/KO) display an elevated emotionality phenotype. We now report that the SERT-KO phenotype is maintained throughout...
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