Article
Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2014
Donaldson Zoe R, Piel David A, Santos Tabia L, Richardson-Jones Jesse, Leonardo E David, Beck Sheryl G, Champagne Frances A, Hen René
Abstract excerpt
The serotonin 1A receptor (5-HT1A) has a major role in modulating the effects of serotonin on mood and behavior. Previous studies have shown that knockout of 5-HT1A selectively in the raphe leads to higher levels of anxiety during adulthood. However, it remains unclear whether this phenotype is due to variation in receptor levels specifically during development or throughout life. To test the hypothesis that...
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