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Article

Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 May 2006

Alexandre Chloé, Popa Daniela, Fabre Véronique, Bouali Saoussen, Venault Patrice, Lesch Klaus-Peter, Hamon Michel, Adrien Joëlle

Abstract excerpt

In serotonin transporter knock-out (5-HTT-/-) mice, extracellular serotonin (5-HT) levels are markedly elevated in the brain, and rapid eye movement sleep (REMS) is enhanced compared with wild-type mice. We hypothesized that such sleep impairment at adulthood results from excessive serotonergic tone during early life. Thus, we assessed whether neonatal treatment with drugs capable of limiting the impact of 5-HT...

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Identifiers

PMID: 16707806
DOI: 10.1523/JNEUROSCI.5156-05.2006
PMCID: PMC6675294

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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