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Article

Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction.

Acta pharmacologica Sinica - 1 Jun 2026

Pochwat Bartłomiej, Masternak Julia, Bobula Bartosz, Bijata Krystian, Chruścicka-Smaga Barbara, Turek Justyna, Hogendorf Adam, Walczak Maria, Smolik Magdalena, Worch Remigiusz, Kusek Magdalena, Bojarski Andrzej J, Tokarski Krzysztof, Szewczyk Bernadeta, Bijata Monika

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression, but their chronic use is associated with side effects and residual symptoms of depression. Both effects induced by SSRIs are mediated by serotonin receptor-dependent signaling pathways, yet the molecular mechanisms underlying these effects remain unclear. Here, we investigated the impact of chronic and acute activation of the...

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Identifiers

PMID: 41634361
DOI: 10.1038/s41401-025-01722-4
PMCID: PMC13197400

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CA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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