Article
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.
Molecular pharmacology - 1 Apr 1998
Bengel D, Murphy D L, Andrews A M, Wichems C H, Feltner D, Heils A, Mössner R, Westphal H, Lesch K P
Abstract excerpt
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT) provides the primary mechanism for inactivation of 5-HT after its release into the synaptic cleft. To further evaluate the function of the 5-HTT, the murine gene was disrupted by homologous recombinatio...
Topics
- Animals
- Autoradiography
- Brain Chemistry
- Carrier Proteins
- Female
- Gene Targeting
- Genotype
- Homeostasis
- Locomotion
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains