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Article

Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2008

Baganz Nicole L, Horton Rebecca E, Calderon Alfredo S, Owens W Anthony, Munn Jaclyn L, Watts Lora T, Koldzic-Zivanovic Nina, Jeske Nathaniel A, Koek Wouter, Toney Glenn M, Daws Lynette C

Abstract excerpt

Mood disorders cause much suffering and are the single greatest cause of lost productivity worldwide. Although multiple medications, along with behavioral therapies, have proven effective for some individuals, millions of people lack an effective therapeutic option. A common serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT expression in vivo and elevates risk for...

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Identifiers

PMID: 19033200
DOI: 10.1073/pnas.0800466105
PMCID: PMC2596260

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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