Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis.

doi:10.1038/srep27563

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Article

Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis.

Scientific reports - 8 Jun 2016

Kim Kwangwoo, Bang So-Young, Ikari Katsunori, Yoo Dae Hyun, Cho Soo-Kyung, Choi Chan-Bum, Sung Yoon-Kyoung, Kim Tae-Hwan, Jun Jae-Bum, Kang Young Mo, Suh Chang-Hee, Shim Seung-Cheol, Lee Shin-Seok, Lee Jisoo, Chung Won Tae, Kim Seong-Kyu, Choe Jung-Yoon, Momohara Shigeki, Taniguchi Atsuo, Yamanaka Hisashi, Nath Swapan K, Lee Hye-Soon, Bae Sang-Cheol

Abstract excerpt

Considerable sharing of disease alleles among populations is well-characterized in autoimmune disorders (e.g., rheumatoid arthritis), but there are some exceptional loci showing heterogenic association among populations. Here we investigated genetic variants with distinct effects on the development of rheumatoid arthritis in Asian and European populations. Ancestry-related association heterogeneity was examined...

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PMID: 27272985
DOI: 10.1038/srep27563
PMCID: PMC4897688

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