Article

Genome-wide analysis of genetic risk factors for rheumatic heart disease in Aboriginal Australians provides support for pathogenic molecular mimicry

2017-09-13

Abstract excerpt

<h4>Background</h4> Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells. <h4>Methods</h4> Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single nucleotide polymorphisms...

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Literature Corpus work: 96bd05b4-4cdf-5edc-919a-11197d7cd2f8
DOI: 10.1101/188334

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