Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.

doi:10.1126/scitranslmed.aag1974

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Article

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.

Science translational medicine - 2 Nov 2016

Dendrou Calliope A, Cortes Adrian, Shipman Lydia, Evans Hayley G, Attfield Kathrine E, Jostins Luke, Barber Thomas, Kaur Gurman, Kuttikkatte Subita Balaram, Leach Oliver A, Desel Christiane, Faergeman Soren L, Cheeseman Jane, Neville Matt J, Sawcer Stephen, Compston Alastair, Johnson Adam R, Everett Christine, Bell John I, Karpe Fredrik, Ultsch Mark, Eigenbrot Charles, McVean Gil, Fugger Lars

Abstract excerpt

Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants in the tyrosine kinase 2 (TYK2) gene, which is differentially associated with common autoimmune diseases, currently...

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Identifiers

PMID: 27807284
DOI: 10.1126/scitranslmed.aag1974
PMCID: PMC5737835

Genes

TYK2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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