Article

<i>cis</i> -eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibility

2022-10-19

Abstract excerpt

The validation of genome-wide association signals for tuberculosis (TB) susceptibility and the development of type 2 diabetes (T2D) across diverse populations remain problematic. The ancestry-specific variants (coding and non-coding) that contribute to previously identified differentially expressed genes (DEG) in patients with TB, T2D and comorbid TB-T2D, remain unknown. Identifying ancestry-specific expression qu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc79f408-4cca-53eb-b277-f6e7bd9e1759
DOI: 10.1101/2022.10.19.512814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>cis</i> -eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibilityDOI 10.1101/2022.10.19.512814Read

Ancestry-Stratified Transcriptome-Wide Association Study Reveals Tissue-Specific Mechanisms of Type 2 Diabetes HeterogeneitySemantic proximity Read

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translationSemantic proximity Read

Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.Semantic proximity Read

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.Semantic proximity Read

Genetic control of the transcriptional response to active tuberculosis disease and treatmentSemantic proximity Read

Ancestry-specific TWAS refines type 2 diabetes GWAS loci in disease-relevant tissuesSemantic proximity Read

Genetic control of the transcriptional response to active tuberculosis disease and treatmentSemantic proximity Read

Multi-ancestry admixture mapping reveals ancestry-associated disease loci in the UK BiobankSemantic proximity Read

Single-Cell Genetic Mapping of Gasdermin Expression Across Immune-Mediated Inflammatory Diseases.Semantic proximity Read

Common genetic determinants of dynamic human in vivo immune response to <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architectureSemantic proximity Read

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.Semantic proximity Read