Article
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
Nature communications - 23 Apr 2015
Yin Xianyong, Low Hui Qi, Wang Ling, Li Yonghong, Ellinghaus Eva, Han Jiali, Estivill Xavier, Sun Liangdan, Zuo Xianbo, Shen Changbing, Zhu Caihong, Zhang Anping, Sanchez Fabio, Padyukov Leonid, Catanese Joseph J, Krueger Gerald G, Duffin Kristina Callis, Mucha Sören, Weichenthal Michael, Weidinger Stephan, Lieb Wolfgang, Foo Jia Nee, Li Yi, Sim Karseng, Liany Herty, Irwan Ishak, Teo Yikying, Theng Colin T S, Gupta Rashmi, Bowcock Anne, De Jager Philip L, Qureshi Abrar A, de Bakker Paul I W, Seielstad Mark, Liao Wilson, Ståhle Mona, Franke Andre, Zhang Xuejun, Liu Jianjun
Abstract excerpt
Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations...
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