Article
A genome-wide cross-trait analysis identifying shared genetic basis and causal relationships between Hunner-type interstitial cystitis and autoimmune diseases in East Asian populations.
Frontiers in immunology - 1 Jan 2024
Lyu Xinyi, Peng Liao, Xu Xueyuan, Fan Yang, Yang Yong, Chen Jiawei, Liu Mengzhu, Chen Yuanzhuo, Zhang Chi, Yang Shiqin, Shen Sihong, Zhang Jie, Zeng Xiao, Shen Hong, Luo Deyi, Lin Yifei
Abstract excerpt
Purpose: Epidemiological studies have demonstrated the clinical link between Hunner interstitial cystitis (HIC) and autoimmune diseases (ADs), suggesting potential shared genetic bases for their comorbidity. We aimed to investigate the shared genetic architecture and causal relationships between HIC and ADs. Methods: We conducted a genome-wide cross-trait study with ~170000 individuals of East Asian ancestry to...
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