Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.

doi:10.1093/hmg/ddt532

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Article

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.

Human molecular genetics - 15 Mar 2014

Kim-Howard Xana, Sun Celi, Molineros Julio E, Maiti Amit K, Chandru Hema, Adler Adam, Wiley Graham B, Kaufman Kenneth M, Kottyan Leah, Guthridge Joel M, Rasmussen Astrid, Kelly Jennifer, Sánchez Elena, Raj Prithvi, Li Quan-Zhen, Bang So-Young, Lee Hye-Soon, Kim Tae-Hwan, Kang Young Mo, Suh Chang-Hee, Chung Won Tae, Park Yong-Beom, Choe Jung-Yoon, Shim Seung Cheol, Lee Shin-Seok, Han Bok-Ghee, Olsen Nancy J, Karp David R, Moser Kathy, Pons-Estel Bernardo A, Wakeland Edward K, James Judith A, Harley John B, Bae Sang-Cheol, Gaffney Patrick M, Alarcón-Riquelme Marta, Looger Loren L, Nath Swapan K

Abstract excerpt

Recent reports have associated NCF2, encoding a core component of the multi-protein NADPH oxidase (NADPHO), with systemic lupus erythematosus (SLE) susceptibility in individuals of European ancestry. To identify ethnicity-specific and -robust variants within NCF2, we assessed 145 SNPs in and around the NCF2 gene in 5325 cases and 21 866 controls of European-American (EA), African-American (AA), Hispanic (HS) and...

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Identifiers

PMID: 24163247
DOI: 10.1093/hmg/ddt532
PMCID: PMC3929085

Genes

NCF2

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