Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry.

The Journal of infectious diseases - 12 Dec 2017

Gray Lesley-Ann, D'Antoine Heather A, Tong Steven Y C, McKinnon Melita, Bessarab Dawn, Brown Ngiare, Reményi Bo, Steer Andrew, Syn Genevieve, Blackwell Jenefer M, Inouye Michael, Carapetis Jonathan R

Abstract excerpt

Background: Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells. Methods: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single-nucleotide polymorphisms were genotyped using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross Reactions
Share to HLA-DQ alpha-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DQ Antigens

Share to Molecular Mimicry

Share to Myosins

Share to Rheumatic Heart Disease

Share to Streptococcal Infections

Share to Streptococcus

Source

Identifiers

PMID: 29029143
DOI: 10.1093/infdis/jix497

Genes

RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry.PMID 29029143Read ↗

Genome-wide analysis of genetic risk factors for rheumatic heart disease in Aboriginal Australians provides support for pathogenic molecular mimicrySemantic proximity Read ↗

The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.Semantic proximity Read ↗

The Human Leukocyte Antigen Locus and Susceptibility to Rheumatic Heart Disease in South Asians and EuropeansSemantic proximity Read ↗

Genetically transitional disease: conceptual understanding and applicability to rheumatic disease.Semantic proximity Read ↗

An immunological perspective on rheumatic heart disease pathogenesis: more questions than answers.Semantic proximity Read ↗

The Genetic Control of the Rheumatic Heart: Closing the Genotype-Phenotype GapSemantic proximity Read ↗

Molecular pathogenesis of rheumatic fever and rheumatic heart diseaseSemantic proximity Read ↗

Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study.Semantic proximity Read ↗

HLA-A29 and Birdshot Uveitis: Further Down the Rabbit HoleSemantic proximity Read ↗

Genetics of rheumatic fever and rheumatic heart diseaseSemantic proximity Read ↗

Human Leukocyte Antigen Determinants in Myocarditis and Dilated Cardiomyopathy.Semantic proximity Read ↗

Rheumatic fever and rheumatic heart disease: cellular mechanisms leading autoimmune reactivity and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.