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Article

An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity.

Briefings in bioinformatics - 1 Mar 2026

Zhang Shuo, Qi Jike, Jiang Yuchen, Lin Hua, Wang Xinyi, Wang Ting, Cao Hongyan, Zeng Ping

Abstract excerpt

Genome-wide association studies (GWASs) have been conducted primarily in European (EUR) populations, limiting insights into underrepresented groups such as East Asian (EAS), but cross-ancestry GWASs have demonstrated high trans-ethnic genetic similarity between EUR and non-EUR populations. To enhance association analysis power in EAS populations, we propose tranScore, a novel summary-statistics-based transfer...

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PMID: 41802284
DOI: 10.1093/bib/bbag103
PMCID: PMC12971055

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