Article

TREM2 R47H exacerbates immune response in Alzheimer’s disease brain

2018-12-19

Abstract excerpt

The R47H variant in the microglial TREM2 receptor is a strong risk factor for Alzheimer’s disease (AD). To characterize processes affected by R47H we performed integrative network analysis of genes expressed in brains of AD patients with R47H, sporadic AD without the variant and patients with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), a systemic disease with early onset d...

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Literature Corpus work: a39ef776-c379-5683-bc24-fb59a770ad58
DOI: 10.1101/499319

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