Article

TREM2-independent neuroprotection is mediated by monocyte-derived macrophages in a mouse model of Alzheimer’s disease

2020-12-02

Abstract excerpt

<title>Abstract</title> The contributions of disease-associated microglia (DAM) and infiltrating monocyte-derived macrophages (MDM) to Alzheimer’s disease (AD) are still controversial. Here, using <italic>Trem2</italic>−/−5xFAD DAM-deficient mice, we addressed this issue by targeting the programmed cell death ligand-1 (PD-L1) immune checkpoint, shown to modify AD via MDM recruitment. Treating <itali...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0097969-eec5-54aa-be3b-5a2013275953
DOI: 10.21203/rs.3.rs-113877/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TREM2-independent neuroprotection is mediated by monocyte-derived macrophages in a mouse model of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-113877/v1Read

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.Semantic proximity Read

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditionsSemantic proximity Read

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer 'if' but 'how'.Semantic proximity Read

TREM2 and the neuroimmunology of Alzheimer's disease.Semantic proximity Read

TREM2 in CNS homeostasis and neurodegenerative disease.Semantic proximity Read

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.Semantic proximity Read

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.Semantic proximity Read

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s DiseaseSemantic proximity Read

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.Semantic proximity Read

Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.Semantic proximity Read

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.Semantic proximity Read