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Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs

12 Oct 2023

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, the regulators of microglial phagocytosis are still unknown. METHODS: We isolated...

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PMID: 37828821
DOI: 10.1002/alz.13502

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