Article
Phenome-wide association study maps new diseases to the human major histocompatibility complex region.
Journal of medical genetics - 1 Oct 2016
Liu Jixia, Ye Zhan, Mayer John G, Hoch Brian A, Green Clayton, Rolak Loren, Cold Christopher, Khor Seik-Soon, Zheng Xiuwen, Miyagawa Taku, Tokunaga Katsushi, Brilliant Murray H, Hebbring Scott J
Abstract excerpt
BACKGROUND: Over 160 disease phenotypes have been mapped to the major histocompatibility complex (MHC) region on chromosome 6 by genome-wide association study (GWAS), suggesting that the MHC region as a whole may be involved in the aetiology of many phenotypes, including unstudied diseases. The phenome-wide association study (PheWAS), a powerful and complementary approach to GWAS, has demonstrated its ability to...
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