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Article

Major histocompatibility complex genomics and human disease.

Annual review of genomics and human genetics - 1 Jan 2013

Trowsdale John, Knight Julian C

Abstract excerpt

Over several decades, various forms of genomic analysis of the human major histocompatibility complex (MHC) have been extremely successful in picking up many disease associations. This is to be expected, as the MHC region is one of the most gene-dense and polymorphic stretches of human DNA. It also encodes proteins critical to immunity, including several controlling antigen processing and presentation....

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Identifiers

PMID: 23875801
DOI: 10.1146/annurev-genom-091212-153455
PMCID: PMC4426292

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