Article

A pan-MHC reference graph with 246 fully contiguous phased sequences

2023-09-04

Abstract excerpt

The major histocompatibility complex (MHC) is a region of the human genome that is key to immune system function but sometimes refractory to genomic analyses due to extreme polymorphism and structural variation. We performed targeted long-read sequencing and de novo assembly of MHC to create 246 highly accurate, fully contiguous, and phased full-length sequences, mostly from data provided by the Human Pangenome R...

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Literature Corpus work: 7900bac1-a509-529a-b592-40065c104962
DOI: 10.1101/2023.09.01.555813

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