Article
Imputation of the major histocompatibility complex region identifies major independent variants associated with bullous pemphigoid and dermatomyositis in Han Chinese.
The Journal of dermatology - 1 Oct 2022
Fan Wencheng, Li Zhuo, Wang Yirui, Zhang Chang, Liu Hao, Wang Daiyue, Bai Yuanming, Luo Sihan, Li Yuanyuan, Qin Qin, Chen Weiwei, Yong Liang, Zhen Qi, Yu Yafen, Ge Huiyao, Mao Yiwen, Cao Lu, Zhang Ruixue, Hu Xia, Yu Yanxia, Li Bao, Sun Liangdan
Abstract excerpt
As autoimmune skin diseases, both bullous pemphigoid (BP) and dermatomyositis (DM) show significant associations with the major histocompatibility complex (MHC) region. In fact, the coexistence of BP and DM has been previously reported. Therefore, we hypothesized that there may be a potential genetic correlation between BP and DM. Based on data for 312 BP patients, 128 DM patients, and 6793 healthy control...
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