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PGG.MHC: toward understanding the diversity of major histocompatibility complexes in human populations.

Nucleic acids research - 6 Jan 2023

Zhao Xiaohan, Ma Sen, Wang Baonan, Jiang Xuetong, Xu Shuhua

Abstract excerpt

The human leukocyte antigen (HLA) system, or the human version of the major histocompatibility complex (MHC), is known for its extreme polymorphic nature and high heterogeneity. Taking advantage of whole-genome and whole-exome sequencing data, we developed PGG.MHC to provide a platform to explore the diversity of the MHC in Asia as well as in global populations. PGG.MHC currently archives high-resolution HLA...

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Alleles
Databases, Genetic
Gene Frequency
Haplotypes
Histocompatibility Antigens Class I

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Histocompatibility Antigens Class II

Major Histocompatibility Complex

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PMID: 36321663
DOI: 10.1093/nar/gkac997
PMCID: PMC9825418

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