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Article

Symmetry breaking in spreading RAT2 fibroblasts requires the MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP and ERK2 signaling.

Biochimica et biophysica acta - 1 Sept 2016

Klímová Zuzana, Bráborec Vojtěch, Maninová Miloslava, Čáslavský Josef, Weber Michael J, Vomastek Tomáš

Abstract excerpt

The spreading of adhering cells is a morphogenetic process during which cells break spherical or radial symmetry and adopt migratory polarity with spatially segregated protruding cell front and non-protruding cell rear. The organization and regulation of these symmetry-breaking events, which are both complex and stochastic, are not fully understood. Here we show that in radially spreading cells, symmetry breaking...

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Source

Identifiers

PMID: 27212270
DOI: 10.1016/j.bbamcr.2016.05.013

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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